Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 4/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985304 | 0.93 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDPDE5AFGFR1 | |
| SCHEMBL10417483 | 0.84 | PDE5A (0.44) | KDM4EALDH1A1HPGDAAK1PDE5A | |
| SCHEMBL10985527 | 0.80 | EGFR (0.32) | KDM4EALDH1A1HPGDSMPD3 | |
| SCHEMBL10417545 | 0.79 | PDE5A (0.42) | KDM4EALDH1A1HPGDAAK1PDE5A | |
| SCHEMBL7272331 | 0.79 | PDE5A (0.45) | KDM4EALDH1A1HPGDAAK1PDE5A | |
| SCHEMBL10988140 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1HPGDPDE5ACDK4 | |
| SCHEMBL10416664 | 0.75 | PDE5A (0.47) | KDM4EALDH1A1HPGDAAK1PDE5A | |
| SCHEMBL10963614 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1HPGDPDE5AAMY1A | |
| SCHEMBL10985310 | 0.74 | ALDH1A1 (0.39) | KDM4EALDH1A1HPGDPDE5AFGFR1 | |
| SCHEMBL7272319 | 0.73 | PDE2A (0.42) | KDM4EALDH1A1HPGDAAK1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4515796-A | INOTROPIC, BRONCHODILATOR, VASODILATORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1985-05-07 | — | — | US | disclosed |