Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10991902 | 0.88 | SLC6A4 (0.40) | SLC6A4SLC6A2KDM4EMAPK1MAPT | |
| SCHEMBL10992307 | 0.86 | SLC6A4 (0.54) | SLC6A4SLC6A2KDM4EMAPK1CYP2D6 | |
| SCHEMBL10985391 | 0.86 | SLC6A4 (0.54) | SLC6A4SLC6A2KDM4EMAPK1CYP2D6 | |
| SCHEMBL10987185 | 0.86 | SLC6A4 (0.39) | SLC6A4SLC6A2KDM4EMAPK1CYP2D6 | |
| SCHEMBL10997868 | 0.86 | SLC6A4 (0.54) | SLC6A4SLC6A2NOS2SLC6A3SIGMAR1 | |
| SCHEMBL10991359 | 0.86 | SLC6A4 (0.39) | SLC6A4SLC6A2KDM4EMAPK1CYP2D6 | |
| SCHEMBL10993181 | 0.86 | SLC6A4 (0.55) | SLC6A4SLC6A2KDM4EMAPK1CYP2D6 | |
| SCHEMBL10995043 | 0.85 | MTNR1A (0.48) | SLC6A4SLC6A2KDM4EMTNR1AMTNR1B | |
| SCHEMBL10993674 | 0.84 | POLB (0.43) | SLC6A4SLC6A2NPSR1MAPTCYP2D6 | |
| SCHEMBL10992162 | 0.84 | SLC6A4 (0.39) | SLC6A4SLC6A2KDM4EGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500541-A | Pharmacologically active cyclopropane derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-02-19 | — | — | US | disclosed |
| EP-0039771-B1 | CYCLOPROPANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | MERCK PATENT GmbH (DE) | 1983-10-19 | — | — | EP | disclosed |