Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL11196663 | 0.98 | DRD2 (0.59) | DRD2SIGMAR1SLC18A3 | |
| Ethylene SCHEMBL11191814 | 0.95 | DRD2 (0.56) | DRD2SIGMAR1SLC18A3 | |
| Fumaric Acid SCHEMBL11183405 | 0.94 | DRD2 (0.54) | DRD2SIGMAR1SLC18A3 | |
| Maleic Acid SCHEMBL10992445 | 0.94 | DRD2 (0.54) | DRD2SIGMAR1SLC18A3 | |
| SCHEMBL10992912 | 0.93 | DRD2 (0.54) | DRD2SIGMAR1SLC18A3KMT2A | |
| SCHEMBL10994028 | 0.93 | DRD2 (0.57) | DRD2SIGMAR1SLC18A3MEN1KMT2A | |
| SCHEMBL10994137 | 0.93 | DRD2 (0.59) | DRD2SIGMAR1SLC18A3 | |
| Bromide SCHEMBL10993860 | 0.92 | DRD2 (0.60) | DRD2SIGMAR1SLC18A3MEN1KMT2A | |
| Ethylene SCHEMBL11194563 | 0.91 | DRD2 (0.59) | DRD2SIGMAR1SLC18A3MEN1KMT2A | |
| SCHEMBL10991466 | 0.91 | SLC18A3 (0.54) | DRD2SIGMAR1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4524207-A | Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4409229-A | Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-10-11 | — | — | US | disclosed |
| EP-0002283-A1 | Substituted 1,3-dihydrospiro (benzo(c)thiophenes), process for their preparation and these compounds for use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-13 | — | — | EP | disclosed |