Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995043 | 0.86 | MTNR1A (0.48) | SLC6A4SLC6A2KDM4ENSD2ALDH1A1 | |
| SCHEMBL10995128 | 0.85 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL11035632 | 0.85 | SLC6A4 (0.40) | SLC6A4SLC6A2KDM4ENSD2ALDH1A1 | |
| SCHEMBL10987628 | 0.85 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL10993889 | 0.85 | CHRNB4 (0.43) | SLC6A4KDM4ENSD2ALDH1A1SMN1; SMN2 | |
| SCHEMBL10993181 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 | |
| SCHEMBL10991064 | 0.83 | SLC6A4 (0.39) | SLC6A4KDM4ENSD2ALDH1A1SMN1; SMN2 | |
| SCHEMBL10991902 | 0.82 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 | |
| SCHEMBL10992130 | 0.82 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10989204 | 0.82 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500541-A | Pharmacologically active cyclopropane derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-02-19 | — | — | US | disclosed |
| EP-0039771-B1 | CYCLOPROPANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | MERCK PATENT GmbH (DE) | 1983-10-19 | — | — | EP | disclosed |
| EP-0039771-A1 | Cyclopropane derivatives, pharmaceutical compositions containing them and processes for their production | MERCK PATENT GmbH (DE) | 1981-11-18 | — | — | EP | disclosed |