Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12458246 | 0.85 | ATM (0.44) | ATML3MBTL1LMNAHPGDCYP2D6 | |
| SCHEMBL8671904 | 0.85 | ATM (0.44) | ATML3MBTL1LMNAHPGDCYP2D6 | |
| SCHEMBL21747696 | 0.81 | ATM (0.53) | ATML3MBTL1TRPA1LMNAADRA2A | |
| Methyl Alcohol SCHEMBL5139174 | 0.80 | SRC (0.46) | ATML3MBTL1LMNACYP2D6 | |
| SCHEMBL195532 | 0.79 | SRC (0.50) | ATML3MBTL1LMNAACP3CYP2D6 | |
| SCHEMBL7955519 | 0.79 | SRC (0.50) | ATML3MBTL1LMNAACP3CYP2D6 | |
| SCHEMBL17363627 | 0.79 | HPGD (0.35) | ATML3MBTL1LMNAHPGDACP3 | |
| SCHEMBL3248502 | 0.79 | CES1 (0.37) | ATML3MBTL1LMNAACP3CYP2D6 | |
| SCHEMBL28044484 | 0.79 | CYP2D6 (0.44) | ATML3MBTL1LMNAACP3CYP2D6 | |
| SCHEMBL4026079 | 0.79 | SRC (0.50) | ATML3MBTL1LMNAACP3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153682-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-10 | — | — | US | disclosed |
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |