Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739933 | 0.89 | MAPT (0.61) | MAPTNPSR1KDM4EGAAKCNH2 | |
| SCHEMBL5179759 | 0.84 | KDM4E (0.69) | KDM4EGAAHTR1ADRD2HTR2A | |
| SCHEMBL5178844 | 0.83 | GAA (0.55) | MAPTKDM4EGAAKCNH2HTR1A | |
| SCHEMBL5178761 | 0.83 | DRD2 (0.65) | MAPTHTR1ADRD2HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11622828 | 0.83 | KDM4E (0.67) | KDM4EGAAHTR1ADRD2HTR2A | |
| SCHEMBL13321082 | 0.83 | KDM4E (0.71) | MAPTNPSR1KDM4EGAAKCNH2 | |
| SCHEMBL11644120 | 0.83 | CYP2D6 (0.70) | MAPTNPSR1KDM4EGAAKCNH2 | |
| SCHEMBL11552613 | 0.83 | MAPT (0.58) | MAPTNPSR1KDM4EGAAKCNH2 | |
| SCHEMBL6637417 | 0.82 | KCNH2 (0.76) | KCNH2HTR1ADRD2HTR2ASIGMAR1 | |
| SCHEMBL10994325 | 0.82 | HSD17B10 (0.73) | KCNH2HTR1ADRD2HTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552878-A | ANTIDEPRESSANTS | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1985-11-12 | — | — | US | disclosed |
| US-3996361-A | ANTIEDEMATOUS, REDUCING CAPILLARY PERMEABILITY | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-12-07 | — | — | US | disclosed |
| US-3932411-A | HYPOTENSIVE, TRANQUILIZERS, SEDATIVES, ANTIEDEMIC | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-01-13 | — | — | US | disclosed |