Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.73 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108376 | 1.00 | P2RX7 (0.73) | P2RX7CACNA1HCACNA1CEGFRKMT2A | |
| SCHEMBL1100939 | 1.00 | P2RX7 (0.73) | P2RX7CACNA1HCACNA1CEGFRKMT2A | |
| SCHEMBL1099994 | 1.00 | P2RX7 (0.73) | P2RX7CACNA1HCACNA1CEGFRKMT2A | |
| SCHEMBL1099211 | 1.00 | P2RX7 (0.73) | P2RX7CACNA1HCACNA1CEGFRKMT2A | |
| SCHEMBL1098727 | 0.89 | P2RX7 (0.81) | P2RX7CACNA1HCACNA1CEGFR | |
| SCHEMBL1099425 | 0.88 | P2RX7 (0.79) | P2RX7CACNA1HCACNA1CEGFR | |
| SCHEMBL1100228 | 0.86 | P2RX7 (0.77) | P2RX7CACNA1HCACNA1CEGFR | |
| SCHEMBL1099777 | 0.85 | P2RX7 (0.66) | P2RX7CACNA1HCACNA1C | |
| SCHEMBL1108394 | 0.85 | P2RX7 (0.66) | P2RX7CACNA1HCACNA1C | |
| SCHEMBL1098826 | 0.85 | P2RX7 (0.76) | P2RX7CACNA1HCACNA1CEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153809-B2 | Dihydropyridone ureas as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-04-10 | — | — | US | disclosed |