Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.69 |
| ▸ | REN | P00797 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | F2 | P00734 | 1/20 | 0.69 |
| ▸ | LTA4H | P09960 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | PEPD | P12955 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
| ▸ | THPO | P40225 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683103 | 1.00 | ACE (0.69) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11497724 | 0.95 | ACE (0.62) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11379775 | 0.86 | ACE (0.65) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11301920 | 0.86 | ACE (0.65) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11379763 | 0.86 | ACE (0.65) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL967588 | 0.85 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17323620 | 0.85 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL6782708 | 0.85 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL3045658 | 0.85 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL6782714 | 0.85 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |