Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.68 |
| ▸ | REN | P00797 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | F2 | P00734 | 1/20 | 0.68 |
| ▸ | LTA4H | P09960 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | PEPD | P12955 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
| ▸ | HRH1 | P35367 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17323620 | 1.00 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL3045658 | 1.00 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6026723 | 0.98 | ACE (0.66) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL16371458 | 0.94 | ACE (0.61) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17323636 | 0.94 | ACE (0.61) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17323637 | 0.94 | ACE (0.61) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL6782714 | 0.89 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL6782708 | 0.89 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL19083734 | 0.88 | ACE (0.53) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17323626 | 0.88 | ACE (0.53) | ACERENLMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101575363-B | The synthetic method of Aplidine and new antitumoral derivatives and preparation and application thereof | PHARMA MAR, S. A. (ES) | 2016-01-27 | — | — | CN | claimed |
| EP-1294747-B1 | SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM | PHARMA MAR SA (ES) | 2008-04-30 | — | — | EP | claimed |
| US-20040097413-A1 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | PHARMA MAR, S.A. (ES) | 2004-05-20 | — | — | US | claimed |
| EP-1294747-A2 | SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM | PHARMA MAR, S.A. (ES) | 2003-03-26 | — | — | EP | claimed |
| WO-2002002596-A2 | SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM | PHARMA MAR, S.A. (ES) | 2002-01-10 | — | — | WO | claimed |
| US-12583835-B2 | Crystal form of nitroxoline prodrug, pharmaceutical composition containing same, and preparation method therefor and application thereof | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2026-03-24 | — | — | US | disclosed |
| EP-4129983-B1 | CRYSTAL FORM OF NITROXOLINE PRODRUG, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | JIANGSU YAHONG MEDITECH CO LTD (CN) | 2024-12-25 | — | — | EP | disclosed |
| CN-115697970-B | Preparation method of aromatic ether compound | 江苏亚虹医药科技股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-115427397-B | Crystal form of nitroquinoline prodrug, pharmaceutical composition containing crystal form, preparation method and application of pharmaceutical composition | 江苏亚虹医药科技股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-20230149567-A1 | MECHANICAL OPENING OF LIPID BILAYERS BY MOLECULAR NANOMACHINES | WILLIAM MARSH RICE UNIVERSITY (US) | 2023-05-18 | — | — | US | disclosed |
| US-20230119296-A1 | CRYSTAL FORM OF NITROXOLINE PRODRUG, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| EP-4129983-A1 | CRYSTAL FORM OF NITROXOLINE PRODRUG, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2023-02-08 | — | — | EP | disclosed |
| US-20050065149-A1 | Neurodegenerative disorders; antiinflammatory agents; strokes; antiischemic agents; neuropathic pain; brain disorders; antiepileptic agents; Parkinson's disease ; amyotropic lateral sclerosis; Alzheimer's disease; antidiabetic agents | PTC THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| US-20050065150-A1 | Lipoxygenase moderators; autoimmune disease; neurodegenerative disease; respiratory system disorders; cardiovascular disorders; Alzheimer's disease; Parkinson's disease; amyotropic lateral sclerosis | PTC THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| US-20050065099-A1 | Alzheimer's disease; Parkinson's disease; brain disorders; antiepileptic agents; amyotrophic lateral sclerosis; vision defects | EDISON PHARMACEUTICALS, INC. | 2005-03-24 | — | — | US | disclosed |
| US-20040097413-A1 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | PHARMA MAR, S.A. (ES) | 2004-05-20 | — | — | US | disclosed |
| EP-1294747-A2 | SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM | PHARMA MAR, S.A. (ES) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002002596-A2 | SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM | PHARMA MAR, S.A. (ES) | 2002-01-10 | — | — | WO | disclosed |
| US-6156724-A | Uses of didemnins as immunomodulating agents | PHARMA MAR, S.A. (ES) | 2000-12-05 | — | — | US | disclosed |
| US-5294603-A | Pharmaceutical compositions containing didemnins | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1994-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097413-A1 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | MCL1, PML, APLNR | ACE 2944/4885REN 3997/4885LMNA 2193/4885 |
| US-20230149567-A1 | MECHANICAL OPENING OF LIPID BILAYERS BY MOLECULAR NANOMACHINES | PLA2G2A, LNPK, EZR | ACE 2550/4885REN 4156/4885LMNA 309/4885 |
| US-20050065149-A1 | Neurodegenerative disorders; antiinflammatory agents; strokes; antiischemic agents; neuropathic pain; brain disorders; antiepileptic agents; Parkinson's disease ; amyotropic lateral sclerosis; Alzheimer's disease; antidiabetic agents | NLN, ACAA2, CS | ACE 1324/4885REN 1490/4885LMNA 1044/4885 |
| US-20050065099-A1 | Alzheimer's disease; Parkinson's disease; brain disorders; antiepileptic agents; amyotrophic lateral sclerosis; vision defects | CLN6, LDHA, NLN | ACE 2312/4885REN 2178/4885LMNA 260/4885 |
| US-20050065150-A1 | Lipoxygenase moderators; autoimmune disease; neurodegenerative disease; respiratory system disorders; cardiovascular disorders; Alzheimer's disease; Parkinson's disease; amyotropic lateral sclerosis | ALOX12, ALOX15, ALOX15B | ACE 1291/4885REN 2367/4885LMNA 981/4885 |
| US-20230119296-A1 | CRYSTAL FORM OF NITROXOLINE PRODRUG, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | CYP4F11, CYP4B1, NOTUM | ACE 1593/4885REN 959/4885LMNA 2977/4885 |
| US-12583835-B2 | Crystal form of nitroxoline prodrug, pharmaceutical composition containing same, and preparation method therefor and application thereof | CYP4B1, NOTUM, CYP1B1 | ACE 2053/4885REN 2266/4885LMNA 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.