Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 10/20 | 0.53 |
| ▸ | INCENP | Q9NQS7 | 10/20 | 0.53 |
| ▸ | TTK | P33981 | 9/20 | 0.53 |
| ▸ | AURKA | O14965 | 8/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10999041 | 0.81 | SIRT3 (0.38) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL10995913 | 0.79 | PIK3CD (0.56) | PDE3BPDE3ALMNAPDE4APDE4B | |
| SCHEMBL10997600 | 0.75 | MEN1 (0.41) | PDE3BPDE3AMAPTTHRBLMNA | |
| SCHEMBL10997700 | 0.74 | AURKB (0.53) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL11004283 | 0.73 | AURKB (0.49) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL11001776 | 0.73 | AURKB (0.57) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL11459784 | 0.70 | AURKB (0.64) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL11555984 | 0.70 | AURKB (0.47) | AURKBINCENPTTKAURKAPDE3B | |
| SCHEMBL10996289 | 0.70 | AURKB (0.51) | AURKBINCENPTTKAURKAPDE3B | |
| Inamrinone SCHEMBL44012 | 0.69 | AURKB (1.00) | AURKBINCENPTTKAURKAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514400-A | Cardiotonic 5-heteroaryl-pyridone | WILLIAM H. RORER, INC. (US) | 1985-04-30 | — | — | US | disclosed |