Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559317 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11003323 | 0.79 | AURKB (0.53) | KDM4EHPGDALDH1A1PDE3APDE3B | |
| SCHEMBL11001549 | 0.76 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10998400 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10996726 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10999041 | 0.75 | SIRT3 (0.38) | PIK3CBKDM4EHPGDALDH1A1PDE3A | |
| SCHEMBL10998578 | 0.72 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10997600 | 0.72 | MEN1 (0.41) | KDM4EALDH1A1PDE3APDE3BLMNA | |
| SCHEMBL7281879 | 0.72 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11002430 | 0.70 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514400-A | Cardiotonic 5-heteroaryl-pyridone | WILLIAM H. RORER, INC. (US) | 1985-04-30 | — | — | US | disclosed |