Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11001937 | 0.89 | PDE10A (0.55) | DPP4MAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5744977 | 0.88 | DPP4 (0.70) | DPP4MAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5744663 | 0.86 | DPP4 (0.65) | DPP4MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5745762 | 0.86 | DPP4 (0.65) | DPP4MAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10705145 | 0.85 | PDE10A (0.56) | DPP4MAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5744910 | 0.83 | DPP4 (0.60) | DPP4SMN1; SMN2KDM4EKMT2AHTT | |
| SCHEMBL5743621 | 0.83 | DPP4 (0.60) | DPP4MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5745244 | 0.83 | DPP4 (0.66) | DPP4MAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL3361845 | 0.83 | DPP4 (1.00) | DPP4MAPTLMNATP53 | |
| SCHEMBL5743886 | 0.82 | DPP4 (0.59) | DPP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559403-A | FOR TREATMENT OF CEREBRAL AND CARDIAC ISCHEMIAS | HOFFMANN-LA ROCHE INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4544657-A | ANTISCHEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1985-10-01 | — | — | US | disclosed |