Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11008827 | 0.78 | CA12 (0.36) | CA9CA12CA1ALDH1A1GAA | |
| SCHEMBL11005895 | 0.77 | CA12 (0.40) | MEN1KMT2ACA9CA12CA1 | |
| SCHEMBL11099356 | 0.76 | MEN1 (0.47) | MEN1KMT2ANPC1STAT3MTOR | |
| SCHEMBL11013941 | 0.76 | TDP1 (0.47) | MEN1KMT2ANPC1STAT3MTOR | |
| SCHEMBL11008843 | 0.72 | VCAM1 (0.41) | MEN1KMT2ANPC1STAT3MTOR | |
| SCHEMBL6479662 | 0.67 | MEN1 (0.75) | MEN1KMT2ANPC1STAT3MTOR | |
| SCHEMBL57257 | 0.67 | VCAM1 (0.61) | MEN1KMT2ANPC1RAD51VCAM1 | |
| SCHEMBL9122070 | 0.67 | HIF1A (0.53) | MEN1KMT2ANPC1STAT3MTOR | |
| SCHEMBL16089350 | 0.67 | VCAM1 (0.61) | MEN1KMT2ANPC1RAD51VCAM1 | |
| SCHEMBL8384330 | 0.67 | KCNJ1 (0.53) | MEN1KMT2ANPC1RAD51VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536507-A | ANTIASTHMA AGENTS | MERCK & CO., INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4394515-A | 10,11-Dihydro-11-oxodibenzo[b,f]thiepin compounds | MERCK & CO., INC. (US) | 1983-07-19 | — | — | US | disclosed |
| EP-0011067-B1 | PROSTAGLANDIN ANTAGONISTS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | disclosed |
| EP-0011067-A1 | Prostaglandin antagonists, their production and their pharmaceutical compositions | MERCK & CO. INC. (US) | 1980-05-28 | — | — | EP | disclosed |
| EP-0000978-A1 | 7-and 8-substituted -10,11-dihydro-11-oxodibenzo (b,f) thiepin derivatives, their production and their parmaceutical compositions | MERCK & CO. INC. (US) | 1979-03-07 | — | — | EP | disclosed |