Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20681335 | 0.84 | SMN1; SMN2 (0.45) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL7015419 | 0.84 | KDM4E (0.54) | KDM4EHSD17B10SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12549201 | 0.75 | CYP2C19 (0.47) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL23085347 | 0.73 | HSD17B10 (0.48) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL5870589 | 0.70 | CYP2C19 (0.65) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5869997 | 0.69 | CYP2C19 (0.62) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL10570426 | 0.69 | KDM4E (1.00) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| Butane SCHEMBL15522319 | 0.67 | KDM4E (0.65) | KDM4ECYP2C19HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL1173887 | 0.66 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL18299809 | 0.66 | TDP1 (0.42) | KDM4EHSD17B10SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4510151-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORPORATION (US) | 1985-04-09 | — | — | US | disclosed |