Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66735 | 0.85 | THRB (1.00) | THRBTDP1PDK2APEX1KDM4E | |
| SCHEMBL11469925 | 0.85 | THRB (1.00) | THRBTDP1PDK2APEX1KDM4E | |
| SCHEMBL30488775 | 0.85 | THRB (1.00) | THRBTDP1PDK2APEX1KDM4E | |
| Bromide SCHEMBL27743796 | 0.83 | THRB (0.95) | THRBTDP1PDK2APEX1KDM4E | |
| Methyl Alcohol SCHEMBL21134117 | 0.81 | THRB (0.91) | THRBTDP1PDK2APEX1KDM4E | |
| Bromomethane SCHEMBL208217 | 0.79 | THRB (0.88) | THRBTDP1PDK2APEX1KDM4E | |
| SCHEMBL28937357 | 0.78 | THRB (0.84) | THRBTDP1PDK2APEX1KDM4E | |
| Dimethylamine SCHEMBL10338435 | 0.78 | THRB (0.84) | THRBTDP1PDK2APEX1KDM4E | |
| SCHEMBL4636492 | 0.76 | THRB (0.68) | THRBTDP1PDK2APEX1KDM4E | |
| SCHEMBL22767920 | 0.74 | THRB (0.65) | THRBTDP1PDK2APEX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153669-B2 | Quaternary ammonium salts as M3 antagonists | NOVARTIS AG (CH) | 2012-04-10 | — | — | US | disclosed |
| US-20090227590-A1 | QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS | NOVARTIS AG (CH) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227590-A1 | QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS | CHRM2, CHRM1, CHRM3 | THRB 492/4885TDP1 3934/4885PDK2 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.