Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11014860 | 0.89 | CYP4F2 (0.36) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL11013239 | 0.86 | TDP1 (0.33) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL11014014 | 0.85 | SMN1; SMN2 (0.33) | HPGDSMN1; SMN2 | |
| SCHEMBL10807256 | 0.82 | TDP1 (0.39) | TDP1CTDSP1KDM4EALDH1A1HPGD | |
| SCHEMBL11011785 | 0.75 | PPARG (0.36) | HPGDSMN1; SMN2PPARD | |
| SCHEMBL10804462 | 0.74 | FFAR4 (0.41) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL9817903 | 0.74 | POLB (0.40) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL10724690 | 0.73 | TDP1 (0.43) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL11011198 | 0.73 | TDP1 (0.37) | TDP1CTDSP1CYP4F2CYP4A11KDM4E | |
| SCHEMBL10805837 | 0.72 | TDP1 (0.41) | TDP1CTDSP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560558-A | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids | ABBOTT LABORATORIES (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0126342-A2 | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids | ABBOTT LABORATORIES (US) | 1984-11-28 | — | — | EP | disclosed |