Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11010349 | 0.85 | TDP1 (0.36) | SMN1; SMN2HPGD | |
| SCHEMBL11011785 | 0.84 | PPARG (0.36) | SMN1; SMN2HPGDHTT | |
| SCHEMBL10804657 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2HTT | |
| SCHEMBL11013656 | 0.82 | S1PR1 (0.33) | SMN1; SMN2HPGDHTT | |
| SCHEMBL10808391 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTT | |
| SCHEMBL10818192 | 0.80 | PPARA (0.36) | SMN1; SMN2 | |
| SCHEMBL10818468 | 0.79 | — | — | |
| SCHEMBL10806857 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2HTT | |
| SCHEMBL10803726 | 0.78 | POLB (0.42) | SMN1; SMN2HPGDHTT | |
| SCHEMBL10803444 | 0.78 | POLB (0.45) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560558-A | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids | ABBOTT LABORATORIES (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0126342-A2 | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids | ABBOTT LABORATORIES (US) | 1984-11-28 | — | — | EP | disclosed |