Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.73 |
| ▸ | PDE5A | O76074 | 3/20 | 0.73 |
| ▸ | PDE1A | P54750 | 3/20 | 0.73 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.73 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.73 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017101 | 0.87 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017458 | 0.85 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016220 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bw-A78U SCHEMBL1883213 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bw-A78U SCHEMBL11014914 | 0.83 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016188 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016243 | 0.81 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016617 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9191632 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11015884 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | claimed |
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | disclosed |