Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.72 |
| ▸ | PDE5A | O76074 | 3/20 | 0.72 |
| ▸ | PDE1A | P54750 | 3/20 | 0.72 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.72 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bw-A78U SCHEMBL1883213 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bw-A78U SCHEMBL11014914 | 0.83 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9194252 | 0.82 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017101 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016220 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11015665 | 0.81 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11015884 | 0.81 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016188 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017458 | 0.80 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11015745 | 0.79 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402752-B1 | N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5155098-A | Analgesics, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5017578-A | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0402752-A1 | N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |