Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015664 | 0.85 | MEN1 (0.42) | MEN1KMT2AALDH1A1ATMMAPT | |
| SCHEMBL11013064 | 0.79 | KDM4E (0.34) | ALDH1A1LMNAHIF1APNPO | |
| Hydrochloric Acid SCHEMBL11016843 | 0.78 | KDM4E (0.37) | MEN1KMT2AALDH1A1LMNAHIF1A | |
| Hydrochloric Acid SCHEMBL11013110 | 0.75 | PNPO (0.33) | ALDH1A1LMNAHIF1APNPO | |
| SCHEMBL11014309 | 0.75 | KDM4E (0.35) | ALDH1A1LMNAHIF1APNPO | |
| SCHEMBL11014182 | 0.74 | PNPO (0.36) | KMT2AALDH1A1LMNAMAPTHIF1A | |
| SCHEMBL11736194 | 0.73 | KDM4E (0.42) | MEN1KMT2AALDH1A1LMNAHIF1A | |
| SCHEMBL11239732 | 0.71 | CYP1A2 (0.33) | ALDH1A1LMNAHIF1APNPO | |
| SCHEMBL11736210 | 0.71 | KDM4E (0.40) | MEN1KMT2AALDH1A1LMNAHIF1A | |
| SCHEMBL11244339 | 0.71 | LMNA (0.41) | MEN1KMT2AALDH1A1LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4546106-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1985-10-08 | — | — | US | disclosed |
| US-4355034-A | Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents | MERCK & CO., INC. (US) | 1982-10-19 | — | — | US | disclosed |
| US-4217352-A | ANTIARTHRITIC AGENT | MERCK & CO., INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4144342-A | ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4061759-A | ANTIINFLAMMATORY, ARTHRITIS | MERCK & CO., INC. (US) | 1977-12-06 | — | — | US | disclosed |