Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.69 |
| ▸ | PDE5A | O76074 | 3/20 | 0.69 |
| ▸ | PDE1A | P54750 | 3/20 | 0.69 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015884 | 0.95 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016243 | 0.83 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016157 | 0.82 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bw-A78U SCHEMBL1883213 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3133797 | 0.82 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016188 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bw-A78U SCHEMBL11014914 | 0.81 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141261 | 0.81 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016220 | 0.80 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017101 | 0.80 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | claimed |
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | disclosed |