Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | PDE5A | O76074 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 2/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015884 | 0.87 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11015745 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3131402 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11016348 | 0.77 | ADORA2A (0.63) | ADORA1 | |
| SCHEMBL10408838 | 0.76 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11452542 | 0.74 | HTT (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL10442061 | 0.73 | CYP1A2 (0.61) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11451374 | 0.73 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8463785 | 0.72 | NFKB1 (0.53) | CYP1A2CYP3A4CYP2D6PKMNFKB1 | |
| SCHEMBL11016243 | 0.72 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | claimed |
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | disclosed |