SCHEMBL1101779

SCHEMBL1101779

COc1ccccc1NC(=O)Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1

nearest known ligand 0.77

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 11/20 0.68
HTR3A P46098 6/20 0.68
HTR3E A5X5Y0 1/20 0.61
HTR3B O95264 1/20 0.61
HTR3D Q70Z44 1/20 0.61
HTR3C Q8WXA8 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1090969 0.99 CHRNA7 (0.67) CHRNA7HTR3AHTR3EHTR3BHTR3D
SCHEMBL1101763 0.91 HTR3A (0.67) CHRNA7HTR3AHTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL1091634 0.90 HTR3A (0.66) CHRNA7HTR3AHTR3EHTR3BHTR3D
SCHEMBL1101989 0.88 CHRNA7 (0.70) CHRNA7HTR3AHTR3EHTR3BHTR3D
SCHEMBL1101798 0.88 HTR3A (0.73) CHRNA7HTR3AHTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL1091022 0.87 CHRNA7 (0.69) CHRNA7HTR3AHTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL1091088 0.87 HTR3A (0.72) CHRNA7HTR3AHTR3EHTR3BHTR3D
SCHEMBL1101782 0.87 CHRNA7 (0.74) CHRNA7HTR3AHTR3EHTR3BHTR3D
SCHEMBL1101986 0.86 HTR3A (0.78) CHRNA7HTR3AHTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL1091628 0.86 CHRNA7 (0.73) CHRNA7HTR3AHTR3EHTR3BHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2022-10-06 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2021-11-04 US disclosed
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2020-04-09 US disclosed
US-10196388-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-02-05 US disclosed
US-20180127409-A1 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-05-10 US disclosed
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2018-02-08 US disclosed
EP-2931315-B1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2017-11-29 EP disclosed
US-9828642-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2017-11-28 US disclosed
WO-2012127393-A1 COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE NOVARTIS AG (CH) 2012-09-27 WO disclosed
EP-2480228-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS Novartis AG (CH) 2012-08-01 EP disclosed
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG 2012-07-05 US disclosed
US-8153799-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2012-04-10 US disclosed
US-8153799-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2012-04-10 US disclosed
WO-2011036167-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2011-03-31 WO disclosed
US-20100324085-A1 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS BAYER SCHERING PHARMA AG (DE) 2010-12-23 US disclosed
US-20100324085-A1 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS BAYER SCHERING PHARMA AG (DE) 2010-12-23 US disclosed
US-7795453-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-09-14 US disclosed
US-7795453-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-09-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885HTR3A 112/4885HTR3E 177/4885
US-20100324085-A1 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 452/4885HTR3E 1133/4885
US-20180127409-A1 AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 452/4885HTR3E 1133/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885HTR3A 131/4885HTR3E 200/4885
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 151/4885HTR3E 416/4885
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885HTR3A 131/4885HTR3E 200/4885
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 151/4885HTR3E 416/4885
US-10196388-B2 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 452/4885HTR3E 1133/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885HTR3A 112/4885HTR3E 177/4885
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885HTR3A 151/4885HTR3E 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.