Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017887 | 1.00 | PDE3B (0.70) | PDE3BPDE3AALDH1A1MGAMGAA | |
| SCHEMBL10620570 | 0.80 | PDE3B (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7280332 | 0.79 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7280326 | 0.79 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11019458 | 0.78 | PDE3B (0.63) | PDE3BPDE3AALDH1A1MGAMGAA | |
| SCHEMBL11019471 | 0.78 | PDE3B (0.63) | PDE3BPDE3AALDH1A1MGAMGAA | |
| SCHEMBL10761737 | 0.77 | PDE3B (0.67) | PDE3BPDE3AALDH1A1GAAPDE4A | |
| SCHEMBL10761194 | 0.76 | PDE3B (0.65) | PDE3BPDE3AGAAPDE4APDE4B | |
| SCHEMBL10759796 | 0.76 | PDE3B (0.69) | PDE3BPDE3AGAAPDE4APDE4B | |
| SCHEMBL7285568 | 0.76 | PDE3B (0.65) | PDE3BPDE3AGAAPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |