Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019458 | 1.00 | PDE3B (0.63) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL11020513 | 0.79 | PDE3B (0.49) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL11020516 | 0.79 | PDE3B (0.49) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL11017887 | 0.78 | PDE3B (0.70) | PDE3BPDE3AGAAALDH1A1MGAM | |
| SCHEMBL11017889 | 0.78 | PDE3B (0.70) | PDE3BPDE3AGAAALDH1A1MGAM | |
| SCHEMBL7280962 | 0.78 | PDE3B (1.00) | PDE3BPDE3ASMN1; SMN2LMNAGAA | |
| SCHEMBL7297228 | 0.76 | PDE3B (1.00) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL7290070 | 0.76 | PDE3B (1.00) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL7282912 | 0.74 | PDE3B (0.66) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL10833710 | 0.74 | PDE3B (0.66) | PDE3BPDE3ARAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |