Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 17/20 | 0.57 |
| ▸ | MME | P08473 | 1/20 | 0.57 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019134 | 1.00 | ACE (0.57) | ACEMMEACE2 | |
| SCHEMBL10813535 | 0.85 | ACE (0.46) | ACEMMEACE2 | |
| SCHEMBL11018354 | 0.82 | ACE (0.56) | ACEMME | |
| SCHEMBL11018351 | 0.82 | ACE (0.56) | ACEMME | |
| SCHEMBL11018346 | 0.82 | ACE (0.56) | ACEMME | |
| SCHEMBL10795369 | 0.79 | ACE (0.80) | ACEMME | |
| SCHEMBL10795378 | 0.79 | ACE (0.80) | ACEMME | |
| SCHEMBL7326895 | 0.77 | ACE (0.52) | ACEMMEACE2 | |
| SCHEMBL7326888 | 0.77 | ACE (0.52) | ACEMMEACE2 | |
| SCHEMBL10808452 | 0.75 | ACE (0.43) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142335-A2 | Lactam containing compounds | E.R. Squibb & Sons, Inc. (US) | 1985-05-22 | — | — | EP | claimed |
| EP-0142335-A2 | Lactam containing compounds | E.R. Squibb & Sons, Inc. (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4474778-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-10-02 | — | — | US | disclosed |