Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 17/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326895 | 1.00 | ACE (0.52) | ACEMMEPIN1CTRB1ACE2 | |
| SCHEMBL7322445 | 0.87 | ACE (0.49) | ACEMMEPIN1CTRB1 | |
| SCHEMBL7436607 | 0.77 | ACE (0.43) | ACEPIN1CTRB1 | |
| SCHEMBL7436611 | 0.77 | ACE (0.43) | ACEPIN1CTRB1 | |
| SCHEMBL7322451 | 0.77 | ACE (0.47) | ACEMMEPIN1CTRB1 | |
| SCHEMBL7322456 | 0.77 | ACE (0.47) | ACEMMEACE2 | |
| SCHEMBL11019134 | 0.77 | ACE (0.57) | ACEMMEACE2 | |
| SCHEMBL11019149 | 0.77 | ACE (0.57) | ACEMMEACE2 | |
| SCHEMBL7321699 | 0.77 | ACE (0.58) | ACEMME | |
| SCHEMBL7321687 | 0.77 | ACE (0.58) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |