Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11885451 | 0.94 | ALDH1A1 (0.57) | ALDH1A1HTTLMNAKDM4ERAB9A | |
| SCHEMBL11019415 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL4117288 | 0.81 | NPC1 (0.60) | ALDH1A1NPSR1KDM4ERAB9AKMT2A | |
| SCHEMBL11024079 | 0.79 | ALDH1A1 (1.00) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL18768744 | 0.78 | ALDH1A1 (0.97) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL22914434 | 0.78 | ALDH1A1 (0.97) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL4117800 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL11025030 | 0.76 | ALDH1A1 (0.70) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL13066481 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HTTNPSR1LMNAHDAC1 | |
| SCHEMBL12169703 | 0.75 | ALDH1A1 (0.52) | ALDH1A1HTTNPSR1LMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081756-B1 | NEW COMPOUNDS WITH ANTIINFLAMMATORY AND ANTITUSSIVE ACTIVITY, PROCESS FOR THEIR PREPARATION AND RELATIVE PHARMACEUTICAL COMPOSITIONS | MEDEA RESEARCH S.r.l. (IT) | 1985-05-15 | — | — | EP | claimed |
| EP-0081756-B1 | NEW COMPOUNDS WITH ANTIINFLAMMATORY AND ANTITUSSIVE ACTIVITY, PROCESS FOR THEIR PREPARATION AND RELATIVE PHARMACEUTICAL COMPOSITIONS | MEDEA RESEARCH S.r.l. (IT) | 1985-05-15 | — | — | EP | disclosed |
| EP-0081756-A1 | New compounds with antiinflammatory and antitussive activity, process for their preparation and relative pharmaceutical compositions | MEDEA RESEARCH S.r.l. (IT) | 1983-06-22 | — | — | EP | disclosed |