Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.54 |
| ▸ | PDE4A | P27815 | 5/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020731 | 0.91 | NPC1 (0.44) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11022051 | 0.90 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11019907 | 0.90 | CHEK2 (0.53) | CHEK2MAPTHDAC6HSP90AA1NPC1 | |
| SCHEMBL11017274 | 0.88 | CHEK2 (0.56) | CHEK2HDAC6HSP90AA1NPC1RAB9A | |
| SCHEMBL11020400 | 0.88 | CHEK2 (0.51) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11017902 | 0.88 | CHEK2 (0.53) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20982494 | 0.86 | CHEK2 (0.62) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11018149 | 0.86 | HDAC6 (0.52) | CHEK2POLBHDAC6HSP90AA1NPC1 | |
| SCHEMBL11019275 | 0.85 | CHEK2 (0.48) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3168707 | 0.82 | HDAC6 (0.62) | CHEK2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |