Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017897 | 0.92 | PDE4A (0.44) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11016463 | 0.91 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11019652 | 0.91 | CHEK2 (0.52) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11020734 | 0.88 | CHEK2 (0.54) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20982494 | 0.83 | CHEK2 (0.62) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11019181 | 0.83 | TP53 (0.55) | CHEK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11016890 | 0.83 | CHEK2 (0.63) | CHEK2TP53 | |
| SCHEMBL11019650 | 0.82 | CHEK2 (0.43) | CHEK2MAPTTP53NPC1RAB9A | |
| SCHEMBL11016458 | 0.82 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL11018943 | 0.80 | AMY1A (0.47) | CHEK2AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |