Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833911 | 0.97 | MAPT (0.50) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9832393 | 0.94 | MAPT (0.39) | MAPTNPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9831795 | 0.93 | MAPT (0.50) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9831655 | 0.90 | MAPT (0.38) | MAPTNPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL11023666 | 0.85 | MAPT (0.39) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9833125 | 0.82 | MAPT (0.54) | MAPTNPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9832729 | 0.79 | MAPT (0.57) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9831749 | 0.79 | MAPT (0.54) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9832386 | 0.79 | MAPT (0.52) | MAPTNPC1POLBCACNA1BAPBA1 | |
| SCHEMBL9831423 | 0.78 | MAPT (0.40) | MAPTNPC1POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |