Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021883 | 0.85 | MAPT (0.47) | MAPTNPC1ALDH1A1HDAC1MEN1 | |
| SCHEMBL9831795 | 0.84 | MAPT (0.50) | MAPTNPC1GAAALDH1A1HDAC1 | |
| SCHEMBL9833125 | 0.83 | MAPT (0.54) | MAPTNPC1GAAALDH1A1MEN1 | |
| SCHEMBL9831655 | 0.82 | MAPT (0.38) | MAPTNPC1GAAALDH1A1MEN1 | |
| SCHEMBL9833911 | 0.81 | MAPT (0.50) | MAPTNPC1GAAALDH1A1HDAC1 | |
| SCHEMBL9832307 | 0.81 | MAPT (0.57) | MAPTNPC1ALDH1A1HDAC1MEN1 | |
| SCHEMBL9831423 | 0.80 | MAPT (0.40) | MAPTNPC1GAAALDH1A1MEN1 | |
| SCHEMBL9832393 | 0.79 | MAPT (0.39) | MAPTNPC1GAAALDH1A1MEN1 | |
| SCHEMBL11024601 | 0.79 | MAPT (0.47) | MAPTNPC1GAAAURKBALDH1A1 | |
| SCHEMBL9832855 | 0.79 | AURKB (0.45) | MAPTNPC1GAAAURKBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |