Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513250 | 0.80 | PDE3A (0.64) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL8195782 | 0.78 | RAB9A (0.50) | HPGDHSD17B10NFKB1KDM4EALDH1A1 | |
| SCHEMBL11019680 | 0.78 | KDM4E (0.46) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL7272616 | 0.74 | KDM4E (0.63) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL11018169 | 0.74 | KDM4E (0.57) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL9460929 | 0.73 | PDE3A (0.70) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL11232009 | 0.72 | KDM4E (0.61) | PDE3APDE4AHPGDBLMHSD17B10 | |
| Olprinone SCHEMBL19205852 | 0.72 | PDE3A (1.00) | PDE3APDE4AHPGDBLMHSD17B10 | |
| Olprinone SCHEMBL27661 | 0.72 | PDE3A (1.00) | PDE3APDE4AHPGDBLMHSD17B10 | |
| SCHEMBL11024615 | 0.71 | KMT2A (0.83) | PDE3APDE4AHPGDBLMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |