Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 18/20 | 0.66 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102058 | 0.88 | MPL (0.63) | MPL | |
| SCHEMBL1106624 | 0.87 | MPL (0.62) | MPLSRD5A1SRD5A2 | |
| SCHEMBL1102185 | 0.86 | MPL (0.84) | MPLSRD5A1SRD5A2 | |
| SCHEMBL1102181 | 0.85 | MPL (0.59) | MPLSRD5A1SRD5A2 | |
| SCHEMBL10079416 | 0.83 | MPL (0.62) | MPLSRD5A1SRD5A2 | |
| SCHEMBL1102106 | 0.83 | MPL (0.62) | MPLSRD5A1SRD5A2 | |
| SCHEMBL1102188 | 0.82 | MPL (0.83) | MPL | |
| SCHEMBL1091676 | 0.80 | MPL (0.62) | MPLSRD5A1SRD5A2 | |
| SCHEMBL14641112 | 0.80 | MPL (0.73) | MPL | |
| SCHEMBL1102203 | 0.80 | MPL (0.73) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153671-B2 | Heterotetracyclic compounds as TPO mimetics | IRM LLC (BM) | 2012-04-10 | — | — | US | disclosed |