Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177039 | 0.75 | MAPT (0.47) | MAPT | |
| SCHEMBL10359156 | 0.74 | MAPT (0.41) | MAPT | |
| SCHEMBL10971228 | 0.71 | CYP1A2 (0.44) | MAPT | |
| SCHEMBL11821261 | 0.70 | BRD4 (0.45) | MAPT | |
| SCHEMBL9347647 | 0.70 | MAPT (0.39) | MAPT | |
| SCHEMBL15821962 | 0.70 | MAPT (0.43) | MAPT | |
| SCHEMBL5210228 | 0.70 | CYP1A2 (0.52) | MAPT | |
| SCHEMBL1414180 | 0.69 | MAPT (0.50) | MAPT | |
| SCHEMBL11832316 | 0.68 | CYP1A2 (0.50) | MAPT | |
| SCHEMBL17919936 | 0.68 | SIGMAR1 (0.50) | MAPTHTR2AHRH1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035244-B1 | CYCLOALKA(4,5)PYRROLO(2,3-G)ISOQUINOLINES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |
| WO-1983000333-A1 | ANTI-HYPERTENSOR, HETEROCYCLICALLY DI-ORTHOSUBSTITUTED PHENOLS | TEULON, JEAN-MARIE | 1983-02-03 | — | — | WO | disclosed |
| EP-0070779-A2 | Di-ortho-substituted phenols of which one of the substitutions is a heterocycle, process for their preparation, anti-hypertensive medicines containing them and synthesis intermediates | CARPIBEM (CENTRE D'ACTIVITE ET DE RECHERCHE PHARMACEUTIQUE INDUSTRIELLE BIOLOGIQUE ET MEDICALE) Société Anonyme dite: (FR) | 1983-01-26 | — | — | EP | disclosed |
| EP-0035244-A2 | Cycloalka(4,5)pyrrolo(2,3-g)isoquinolines, processes and intermediates for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-09-09 | — | — | EP | disclosed |