Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.70 |
| ▸ | EYA2 | O00167 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | ACE | P12821 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21539376 | 0.97 | TDP1 (0.75) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL6151050 | 0.97 | TDP1 (0.75) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL8988039 | 0.97 | TDP1 (0.68) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL22571480 | 0.95 | TDP1 (0.70) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL18251067 | 0.95 | TDP1 (0.65) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL1698787 | 0.95 | TDP1 (0.74) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL5521524 | 0.92 | TDP1 (0.75) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL19962177 | 0.92 | TDP1 (0.75) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL17022264 | 0.91 | TDP1 (0.58) | TDP1ALOX15KDM4EBLMPMP22 | |
| SCHEMBL13260725 | 0.90 | TDP1 (0.59) | TDP1ALOX15KDM4EBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068443-B1 | RESIDUALIZING LINKERS AND USES THEREOF | CENTRE FOR PROBE DEV AND COMMERCIALIZATION (CA) | 2019-04-10 | — | — | EP | disclosed |
| US-20160279272-A1 | RESIDUALIZING LINKERS AND USES THEREOF | CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION (CA) | 2016-09-29 | — | — | US | disclosed |
| US-8153784-B2 | Imaging of enzyme activity | THE GENERAL HOSPITAL CORPORATION (US) | 2012-04-10 | — | — | US | disclosed |
| US-20080044827-A1 | Imaging of Enzyme Activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044827-A1 | Imaging of Enzyme Activity | GBA3, BCHE, MGAM | TDP1 439/4885ALOX15 2020/4885KDM4E 2901/4885 |
| US-20160279272-A1 | RESIDUALIZING LINKERS AND USES THEREOF | CD44, CD47, MTCL3 | TDP1 2242/4885ALOX15 1362/4885KDM4E 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.