Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021482 | 0.94 | MAPT (0.46) | MAPTNPC1GAAAURKBKDM4E | |
| SCHEMBL9833228 | 0.87 | MAPT (0.55) | MAPTNPC1GAAABCB1ABCC1 | |
| SCHEMBL9832909 | 0.86 | AURKB (0.42) | MAPTNPC1GAAAURKBKDM4E | |
| SCHEMBL9832029 | 0.85 | MAPT (0.55) | MAPTNPC1ABCB1ABCC1MEN1 | |
| SCHEMBL9833480 | 0.84 | MAPT (0.55) | MAPTNPC1GAAABCB1ABCC1 | |
| SCHEMBL9831010 | 0.84 | MAPT (0.41) | MAPTNPC1GAAKDM4ELMNA | |
| SCHEMBL9833445 | 0.83 | AURKB (0.44) | MAPTNPC1GAAAURKBKDM4E | |
| SCHEMBL9831603 | 0.83 | AURKB (0.42) | MAPTGAAAURKBKDM4EPKM | |
| SCHEMBL11025524 | 0.82 | MAPT (0.52) | MAPTNPC1GAAABCB1ABCC1 | |
| SCHEMBL9831368 | 0.82 | MAPT (0.55) | MAPTNPC1ABCB1ABCC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |