Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833228 | 0.96 | MAPT (0.55) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL11021482 | 0.91 | MAPT (0.46) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL9833205 | 0.89 | MAPT (0.43) | MAPTNPC1ALDH1A1GAAPOLB | |
| SCHEMBL9831368 | 0.88 | MAPT (0.55) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL9834020 | 0.86 | MAPT (0.56) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL9831010 | 0.85 | MAPT (0.41) | MAPTNPC1ALDH1A1GAAPOLB | |
| SCHEMBL11023902 | 0.84 | MAPT (0.43) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL9832029 | 0.84 | MAPT (0.55) | MAPTNPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL9831603 | 0.83 | AURKB (0.42) | MAPTALDH1A1GAAMEN1RAB9A | |
| SCHEMBL11025524 | 0.83 | MAPT (0.52) | MAPTNPC1ABCB1ABCC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |