Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026370 | 0.86 | ACE (0.68) | ACE | |
| SCHEMBL11025701 | 0.82 | ACE (0.61) | ACEXIAP | |
| SCHEMBL11023988 | 0.81 | ACE (0.60) | ACE | |
| SCHEMBL10952228 | 0.80 | ACE (0.61) | ACE | |
| SCHEMBL11025138 | 0.76 | ACE (0.90) | ACE | |
| SCHEMBL10956427 | 0.75 | ACE (0.92) | ACE | |
| SCHEMBL11023970 | 0.74 | ACE (0.68) | ACE | |
| SCHEMBL10896677 | 0.74 | ACE (0.50) | ACEXIAP | |
| SCHEMBL10915073 | 0.74 | ACE (0.50) | ACEXIAP | |
| SCHEMBL10793023 | 0.72 | ACE (0.51) | ACEXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049842-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES, A PROCESS FOR THE PREPARATION AND A PHARMACEUTICAL COMPOSITION USEFUL IN THE TREATMENT OF HYPERTENSION COMPRISING THE SAME, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4396616-A | DIURETICS, ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1983-08-02 | — | — | US | disclosed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | disclosed |