Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.68 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025138 | 0.87 | ACE (0.90) | ACEITGB3ITGA2B | |
| SCHEMBL11029962 | 0.86 | ACE (0.57) | ACESMN1; SMN2 | |
| SCHEMBL10956427 | 0.85 | ACE (0.92) | ACEITGB3ITGA2B | |
| SCHEMBL11025704 | 0.81 | ACE (0.47) | ACEITGB3ITGA2BCYP1A2MAPK1 | |
| SCHEMBL11023989 | 0.80 | ACE (0.64) | ACEITGB3ITGA2BCYP1A2MAPK1 | |
| SCHEMBL10951566 | 0.77 | ACE (0.68) | ACEITGB3ITGA2B | |
| SCHEMBL11023967 | 0.74 | ACE (0.90) | ACE | |
| SCHEMBL11264281 | 0.74 | MAPK1 (0.39) | ACECYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL11280204 | 0.74 | MAPK1 (0.39) | ACECYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL11255094 | 0.72 | ACE (0.39) | ACEITGB3ITGA2BCYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049842-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES, A PROCESS FOR THE PREPARATION AND A PHARMACEUTICAL COMPOSITION USEFUL IN THE TREATMENT OF HYPERTENSION COMPRISING THE SAME, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | disclosed |