Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241680 | 1.00 | BACE1 (0.33) | BACE1KIF11HSP90AA1 | |
| SCHEMBL2632298 | 1.00 | BACE1 (0.33) | BACE1KIF11HSP90AA1 | |
| SCHEMBL2619911 | 1.00 | BACE1 (0.33) | BACE1KIF11HSP90AA1 | |
| SCHEMBL2107163 | 1.00 | BACE1 (0.33) | BACE1KIF11HSP90AA1 | |
| Benzoic Acid SCHEMBL11025567 | 0.93 | BACE1 (0.35) | BACE1HSP90AA1 | |
| SCHEMBL18597917 | 0.93 | KIF11 (0.32) | BACE1KIF11HSP90AA1 | |
| SCHEMBL11888115 | 0.93 | KIF11 (0.32) | BACE1KIF11HSP90AA1 | |
| SCHEMBL11888112 | 0.93 | KIF11 (0.32) | BACE1KIF11HSP90AA1 | |
| SCHEMBL18598089 | 0.93 | KIF11 (0.32) | BACE1KIF11HSP90AA1 | |
| SCHEMBL18597919 | 0.93 | KIF11 (0.32) | BACE1KIF11HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |
| US-8962858-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962858-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-8802871-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8802871-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8426584-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-8426584-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | BACE1 2/4885KIF11 4773/4885HSP90AA1 2212/4885 |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | BACE1 2/4885KIF11 4773/4885HSP90AA1 2212/4885 |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | BACE1 2/4885KIF11 4773/4885HSP90AA1 2212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.