Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | GPR183 | P32249 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ME2 | P23368 | 1/20 | 0.56 |
| ▸ | ME1 | P48163 | 1/20 | 0.56 |
| ▸ | ME3 | Q16798 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026534 | 1.00 | POLB (0.67) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL27585181 | 0.86 | POLB (0.67) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL16599447 | 0.84 | KMT2A (0.89) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL4456981 | 0.84 | KMT2A (0.89) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL16599448 | 0.84 | KMT2A (0.89) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL5707169 | 0.84 | MEN1 (0.85) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL3159223 | 0.84 | MEN1 (0.85) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL16599130 | 0.83 | GPR183 (0.77) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL16599132 | 0.83 | GPR183 (0.77) | POLBMEN1KMT2AGPR183ALDH1A1 | |
| SCHEMBL27295942 | 0.82 | GPR183 (0.74) | POLBMEN1KMT2AGPR183ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |