Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020707 | 0.83 | PDE3B (0.40) | DAOKMT2AGRM2KDM4EHPGD | |
| SCHEMBL11021760 | 0.81 | DAO (0.44) | DAOKMT2ADHFRHTTKDM4E | |
| SCHEMBL11021220 | 0.79 | HSD11B1 (0.46) | DAOTSHRHTTKDM4EALDH1A1 | |
| SCHEMBL11026202 | 0.76 | KDM4E (0.56) | DAOKMT2ABRD4POLBKDM4E | |
| SCHEMBL11023987 | 0.75 | DAO (0.42) | DAOKMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9356557 | 0.75 | CYP3A4 (0.44) | DAOCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL103159 | 0.74 | MAPT (0.49) | CYP3A4CYP2C9KMT2AHTTPOLB | |
| SCHEMBL18796800 | 0.73 | PDE3B (0.68) | CA2DAOCYP3A4CYP2C9TSHR | |
| SCHEMBL11021852 | 0.72 | PNP (0.40) | CYP3A4TSHRCYP2C19PDE4APDE4B | |
| SCHEMBL11021805 | 0.71 | KDM4E (0.45) | DAOKMT2ABRD4POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |