Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL15635708 | 0.78 | SMN1; SMN2 (0.43) | APPSNCAHIF1AALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL4905471 | 0.77 | KCNQ2 (0.43) | APPSNCAHIF1AALDH1A1CYP3A4 | |
| Bromide SCHEMBL28015267 | 0.77 | SMN1; SMN2 (0.42) | APPSNCAHIF1AALDH1A1CYP3A4 | |
| Bromide SCHEMBL4179733 | 0.75 | SNCA (0.50) | APPSNCAHIF1A | |
| Hydrochloric Acid SCHEMBL10522550 | 0.75 | SMN1; SMN2 (0.43) | APPSNCAHIF1AALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL8068055 | 0.73 | SMN1; SMN2 (0.45) | APPSNCAHIF1AALDH1A1CYP3A4 | |
| Bromide SCHEMBL10346914 | 0.72 | SNCA (0.50) | APPSNCAHIF1AALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL3638045 | 0.72 | SNCA (0.47) | APPSNCAHIF1A | |
| Bromide SCHEMBL163158 | 0.70 | SNCA (0.67) | APPSNCAHIF1AALDH1A1TSHR | |
| Bromide SCHEMBL39844 | 0.70 | SNCA (0.73) | APPSNCAHIF1AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085030-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED DIVINYL PYRIDINES, AND SUBSTITUTED DIVINYL PYRIDINES | CIBA-GEIGY AG (CH) | 1985-05-22 | — | — | EP | disclosed |
| US-4477673-A | Process for the preparation of substituted divinylpyridines and novel substituted divinylpyridines | CIBA-GEIGY CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0103538-A2 | Copolymers of vinylpyridine, process for their preparation and their use as sulphonate reagents | CIBA-GEIGY AG (CH) | 1984-03-21 | — | — | EP | disclosed |
| EP-0085030-A1 | Process for the preparation of substituted divinyl pyridines, and substituted divinyl pyridines | CIBA-GEIGY AG (CH) | 1983-08-03 | — | — | EP | disclosed |