Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 4/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.57 |
| ▸ | MERTK | Q12866 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024939 | 0.89 | MET (0.64) | METCYP3A4CYP2C9RIPK3RIPK1 | |
| SCHEMBL11888357 | 0.88 | AURKA (0.49) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL1160885 | 0.87 | MET (0.62) | METCYP3A4CYP2C9RIPK3RIPK1 | |
| SCHEMBL11028938 | 0.86 | MET (0.60) | METCYP3A4CYP2C9RIPK3RIPK1 | |
| SCHEMBL11027298 | 0.84 | KDR (0.46) | METCYP3A4CYP2C9RIPK3RIPK1 | |
| SCHEMBL11029810 | 0.84 | MEN1 (0.46) | METKDRAXL | |
| SCHEMBL11050470 | 0.84 | MST1R (0.47) | METKDRAXL | |
| SCHEMBL11030863 | 0.83 | MST1R (0.47) | METKDRAXL | |
| SCHEMBL11031908 | 0.83 | MST1R (0.45) | METKDR | |
| SCHEMBL15552902 | 0.83 | MET (0.70) | METCYP3A4CYP2C9RIPK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569295-B2 | Bicyclic urea compounds | MERCK PATENT GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| US-8569295-B2 | Bicyclic urea compounds | MERCK PATENT GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| EP-2461869-B1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-08-21 | — | — | EP | disclosed |
| US-20120190654-A1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2012-07-26 | — | — | US | disclosed |
| WO-2011017142-A1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190654-A1 | NOVEL BICYCLIC UREA COMPOUNDS | CCNC, CCNI, CCNA1 | MET 1111/4885CYP3A4 1640/4885CYP2C9 1819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.