Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | MDH1 | P40925 | 2/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 4/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334879 | 1.00 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL11030754 | 1.00 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL2402292 | 1.00 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL181229 | 1.00 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL7338653 | 1.00 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL20178553 | 0.94 | CYP4A11 (0.54) | CYP4A11CYP4F2MDH1DHODHMAPT | |
| SCHEMBL6069166 | 0.85 | CYP4A11 (0.73) | CYP4A11CYP4F2MAPTSMN1; SMN2HAO1 | |
| SCHEMBL14660877 | 0.85 | CYP4A11 (0.73) | CYP4A11CYP4F2MAPTSMN1; SMN2HAO1 | |
| SCHEMBL12814607 | 0.85 | CYP4A11 (0.73) | CYP4A11CYP4F2MAPTSMN1; SMN2HAO1 | |
| SCHEMBL10986414 | 0.85 | CYP4A11 (0.73) | CYP4A11CYP4F2MAPTSMN1; SMN2HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673882-B2 | Inhibitors of autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2012100018-A1 | INHIBITORS OF AUTOTAXIN | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | WO | disclosed |
| US-20120190650-A1 | Inhibitors of Autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190650-A1 | Inhibitors of Autotaxin | ENPP2, PHPT1, PSPH | CYP4A11 4081/4885CYP4F2 4487/4885MDH1 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.