Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 15/20 | 0.51 |
| ▸ | NPC1 | O15118 | 14/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 7/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427073 | 0.89 | RAB9A (0.63) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL31731985 | 0.84 | RAB9A (0.67) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL13325909 | 0.74 | RAB9A (0.83) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL29372978 | 0.73 | RAB9A (0.59) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL11029689 | 0.73 | PTGS1 (0.40) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL31154574 | 0.73 | RAB9A (0.74) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL13325938 | 0.73 | RAB9A (0.80) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL966793 | 0.73 | RAB9A (0.74) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL29080554 | 0.73 | RAB9A (0.74) | RAB9ANPC1KDM4EPOLBPKM | |
| SCHEMBL13131131 | 0.73 | RAB9A (0.69) | RAB9ANPC1KDM4EPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | RAB9A 677/4885NPC1 732/4885KDM4E 1665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.