Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 4/20 | 0.78 |
| ▸ | ADH1A | P07327 | 4/20 | 0.78 |
| ▸ | ADH1C | P00326 | 3/20 | 0.62 |
| ▸ | ADH7 | P40394 | 2/20 | 0.62 |
| ▸ | ADH4 | P08319 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658308 | 0.88 | ADH1B (1.00) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL115609 | 0.88 | — | — | |
| SCHEMBL21997344 | 0.88 | ADH1B (1.00) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL23573316 | 0.85 | ADH1B (0.64) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL10437988 | 0.85 | ADH1B (0.64) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL8863326 | 0.85 | ADH1B (0.64) | ADH1BADH1AADH1CADH7ADH4 | |
| Hydrochloric Acid SCHEMBL4095046 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL9205102 | 0.85 | — | — | |
| Dimethylcarbate SCHEMBL11114306 | 0.84 | ADH1B (0.61) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL21088347 | 0.82 | ADH1B (0.88) | ADH1BADH1AADH1CADH7ADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073391-B1 | METAL COMPLEXES OF 1-AMINOCYCLOPROPANE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PLANT GROWTH REGULATORS | BAYER AG (DE) | 1985-03-06 | — | — | EP | disclosed |
| EP-0057357-B1 | PLANT GROWTH STUNTING AGENT | BAYER AG (DE) | 1984-07-25 | — | — | EP | disclosed |
| EP-0073391-A1 | Metal complexes of 1-aminocyclopropane-carboxylic acids, process for their preparation and their use as plant growth regulators | BAYER AG (DE) | 1983-03-09 | — | — | EP | disclosed |
| EP-0066760-A2 | Derivatives of 1-amino-cyclopropanecarboxylic acid, process for their preparation and their use as plant growth regulators | BAYER AG (DE) | 1982-12-15 | — | — | EP | disclosed |
| EP-0057357-A2 | Plant growth stunting agent | BAYER AG (DE) | 1982-08-11 | — | — | EP | disclosed |
| EP-0005782-B1 | PLANT GROWTH REGULANTS AND COMPOSITIONS CONTAINING THEM, THEIR APPLICATION AND THEIR PREPARATION | BAYER AG (DE) | 1982-02-24 | — | — | EP | disclosed |
| EP-0005782-A1 | Plant growth regulants and compositions containing them, their application and their preparation | BAYER AG (DE) | 1979-12-12 | — | — | EP | disclosed |