Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28418972 | 0.88 | POLB (0.50) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL5930579 | 0.87 | CA12 (0.44) | P2RY12CA12CA1CA2CA9 | |
| SCHEMBL8706578 | 0.85 | GAA (0.46) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL27481741 | 0.83 | GAA (0.50) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL28469697 | 0.82 | ACE (0.47) | GAA | |
| Hydrochloric Acid SCHEMBL10538267 | 0.81 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| Hydrochloric Acid SCHEMBL10538264 | 0.81 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL28187611 | 0.81 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL60371 | 0.80 | GAA (0.62) | GAAMMP8KMT2ANAALAD2 | |
| SCHEMBL60370 | 0.80 | GAA (0.62) | GAAMMP8KMT2ANAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045171-B1 | 9-AMINO-1-HYDROXYOCTAHYDROBENZO(C)QUINOLINES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1985-02-13 | — | — | EP | disclosed |