Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.86 |
| ▸ | HRH2 | P25021 | 8/20 | 0.83 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Burimamide SCHEMBL26626246 | 0.91 | HRH2 (1.00) | HRH4HRH2HRH3 | |
| SCHEMBL8964986 | 0.80 | HRH3 (0.79) | HRH4HRH2HRH3 | |
| SCHEMBL8963957 | 0.78 | HRH3 (0.80) | HRH4HRH2HRH3 | |
| SCHEMBL5512404 | 0.75 | QPCT (0.58) | HRH4HRH2HRH3 | |
| SCHEMBL8963886 | 0.75 | HRH3 (0.75) | HRH4HRH2HRH3 | |
| SCHEMBL4687435 | 0.74 | HRH3 (0.66) | HRH4HRH2HRH3 | |
| SCHEMBL11359146 | 0.73 | HRH2 (0.71) | HRH4HRH2HRH3 | |
| SCHEMBL1515167 | 0.72 | — | — | |
| SCHEMBL12216019 | 0.72 | HRH3 (0.79) | HRH4HRH2HRH3 | |
| SCHEMBL2005145 | 0.71 | HRH3 (0.61) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499101-A | HISTAMINE H2-ANTAGONISTS; ANTISECRETORY ANTIINFLAMMOATORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-12 | — | — | US | disclosed |
| US-4388319-A | ANTIHISTAMINES, ANTISECRETORY, ANTIINFLAMMATORY, HYPOTENSIVE AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-06-14 | — | — | US | disclosed |
| US-4271169-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-06-02 | — | — | US | disclosed |
| US-4215125-A | H-2 HISTAMINE RECEPTOR INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-29 | — | — | US | disclosed |
| US-4152443-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-01 | — | — | US | disclosed |
| US-4112104-A | UREA, THIOUREA OR GUANIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-09-05 | — | — | US | disclosed |
| US-4025527-A | H-2 HISTAMINE RECEPTOR INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-24 | — | — | US | disclosed |